A fierce divisional rivalry will take place this Thursday Night Football when the San Francisco 49ers visit the Los Angeles Rams for the opening of Week 5 in a match that sets the first-place team in the NFC West division after all their teams finish Week 4 with a record of 3-1, except for the Cardinals, who are 2-2. Here is our BossAction prediction.
49ers vs Rams Key Game Details
- Date: Thursday, October 2nd
- Time: 8:15 p.m. ET.
- Broadcast: Prime Video
- Stadium: SoFi Stadium
San Francisco 49ers Injury Status and Outlook
San Francisco entered Week 4 with a 3-0 record, which was dropped after a 26-21 loss against Jacksonville in Santa Clara, California, while Los Angeles pulled out a 27-20 win over Indiana Jones and the Colts on Sunday. The Rams (3-1) are 2-0 on their home field this season, and this Thursday, they have the opportunity to enhance that situation. The 49ers (3-1), who are 3-0 in the conference, have a perfect record on the road, which means one of them will lose their perfect record.
For this game, the 49ers must deal with multiple injuries, such as Nick Bosa, Jauan Jennings, George Kittle, Ricky Pearsall, Brandon Aiyuk, and most recently the quarterback Brock Purdy, who has been ruled out, as everything points to the return of Mac Jones to the starting lineup, which gives the Rams a solid chance to beat a vulnerable Niners on their own turf. Some critics even considered the 49ers’ perfect record to be the most mirage-like thing in the league, and the game against the Jaguars exposed that, which is why the odds favor the Rams.
#TNFonPrime under the Hollywood lights 🌟 pic.twitter.com/LO7f9N0FPp
— NFL on Prime Video (@NFLonPrime) October 1, 2025
Los Angeles Rams Recent Player Statistics
The Los Angeles Rams, 2022 champions, have some important players on their roster who are filling every Rams fan with high hopes for a season that ends on February 8th. The quarterback, Matthew Stafford, has accomplished 92 completions out of 136 attempts (67% completion percentage) for 1,114 yards and eight touchdowns, including an 88-yard touchdown in the last game.
In the rushing game, Kyren Williams, the running back, has 303 yards in 68 carries and one touchdown, while his teammate Blake Corum has reached 120 yards in 23 carries with one touchdown as well. In the air, the wide receiver Puka Nacua has proved to be one of the best receivers in the league, with 503 yards in 42 receptions. The other WR, the veteran Davante Adams, has scored three touchdowns in just 269 yards.
Our Final 49ers vs Rams Score Prediction
The ‘Battle of California’ is more than just a geographic rivalry; it’s a historic, intense NFL clash dating back to 1950. Defined by incredible showdowns, generational talents, and legendary coaches, the two annual matchups are always must-watch football. From the 49ers’ dominating 17-game win streak in the ’90s to the high-stakes 2021 NFC Championship, this rivalry delivers highlights. Given the current circumstances and momentum, we believe the Rams have the slight edge this time around. Our official prediction at BossAction: 49ers 21 – 28 Rams.
